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Title

P234- IDE2 EFFICIENTLY DIRECT ENDODERMAL DIFFERENTIATION OF MOUSE EMBRYONIC STEM CELLS

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Abstract

 OBJECTIVE: EMBRYONIC STEM CELLS ARE PLURIPOTENT CELLS WITH THE ABILITY TO DIFFERENTIATE IN VIVO AND IN VITRO INTO ALL CELL TYPES OF THE EMBRYO PROPER. HOWEVER, HOW TO EFFICIENTLY DIRECT THEM TO BECOME SPECIFIC TYPE OF CELLS REMAINS A GREAT CHALLENGE TO THE FIELD. MOST PROTOCOLS DEVELOPED FOR DIRECTED DIFFERENTIATION HAVE RELIED ON EXTRACELLULAR MOLECULES AND GENE REGULATORY FACTORS ESSENTIAL FOR NORMAL DIFFERENTIATION OF CELLS IN EMBRYONIC DEVELOPMENT. SINCE THESE FACTORS ARE PROTEIN-BASED MATERIAL, THEY ARE DIFFICULT TO OBTAIN AND COSTLY FOR LARGE SCALE DIFFERENTIATION. BY SCREENING SMALL MOLECULE LIBRARIES FOR COMPOUNDS THAT PROMOTE EMBRYONIC STEM CELL (ESC) DIFFERENTIATION, SEVERAL GROUPS HAVE REPORTED THEIR RECENT SUCCESS IN EFFICIENTLY CONTROLLING ESC DIFFERENTIATION TO ENDODERM VIA SMALL MOLECULES. THIS STUDY AIMS WAS TO DIFFERENTIATE MOUSE EMBRYONIC STEM CELLS (MESCS) INTO DEFINITIVE ENDODERM BY SMALL MOLECULES SUCH AS IDE2 INSTEAD OF USING PROTEIN-BASED MATERIAL SUCH AS ACTIVIN A...

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