Seminar Paper

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Information Seminar Paper

Title

P231- A PROTOCOL FOR PRODUCTION OF FUNCTIONALLY ACTIVE HEPATOCYTE-LIKE CELLS FROM HUMAN ADIPOSE TISSUE DERIVED STEM CELLS

Pages

 Start Page | End Page

Keywords

HUMAN ADIPOSE TISSUE DERIVED STEM CELLS (HADSCS) 

Abstract

 OBJECTIVE: HUMAN ADIPOSE TISSUE DERIVED STEM CELLS (HADSCS) ARE CONSIDERED AS A PROMISING CANDIDATE FOR CELL THERAPY OF END-STAGE LIVER DISEASES. THEY POSSESS THE SPECIAL AFFINITY TO ACQUIRE HEPATOCYTE FUNCTIONS ALONGSIDE OF LONGEST CULTURE PERIOD AND HIGHEST POTENTIAL COMPARED TO MESENCHYMAL STEM CELLS (MSCS) DERIVED FROM OTHER SOURCES. SO FAR, WIDE VARIETIES OF STRATEGIES HAVE BEEN EMPLOYED FOR IN VITRO STEM CELL DIFFERENTIATION TOWARD HEPATOCYTE-LIKE CELLS, ALTHOUGH THE HEPATIC DIFFERENTIATION STATUS OF THESE CELLS HAS NOT BEEN SUFFICIENT FOR CLINICAL USE MAINLY BECAUSE THEIR METABOLIC ACTIVITIES ARE NOT FULLY INDUCED. THE AIM OF PRESENT STUDY WAS TO EXPLAIN A NEW PROTOCOL FOR THE EFFICIENT HEPATIC DIFFERENTIATION OF HADSCS...

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