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Title

P224- TELOMERASE ACTIVITY IS ASSOCIATED WITH THE GROWTH RATE OF HUMAN UMBILICAL CORD-DERIVED MESENCHYMAL STEM CELLS

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Abstract

 OBJECTIVE: HUMAN UMBILICAL CORD-DERIVED MESENCHYMAL STEM CELLS (HUCMSCS) ARE PERINATAL STEM CELLS DIFFERENTIATING INTO VARIOUS GERM LAYER DERIVATIVES INCLUDING NEURAL CELLS AND CARDIOMYOCYTES. THEY HAVE A SELF-RENEWAL CAPACITY AND MAINTAIN THEIR GREAT PROLIFERATIVE STATUS THROUGH HIGHLY TELOMERASE ACTIVITY. TELOMERE IS A REPEATED TTAGGG SEQUENCE LOCATED AT THE END OF THE CHROMOSOME AND SHORTENS SEQUENTIALLY WITH PROMOTION OF PROLIFERATION IN SOMATIC CELLS BUT THE HIGHER PROLIFERATIVE CELLS SUCH AS CANCER AND STEM CELLS EXTENSIVELY EXPRESS THE TELOMERASE TO ESCAPE THE CELL AGING. IT IS AN RIBONUCLEOPROTEIN ENZYME WITH REVERSE TRANSCRIPTASE ACTIVITY AND HAS AN ESSENTIAL ROLE IN TELOMERE MAINTENANCE. WE BELIEVE THAT THE PASSAGE NUMBER BY WHICH THE CELLS WILL BE EXPANDED IS VERY IMPORTANT FOR PROLIFERATION AND DIFFERENTIATION. SO, THIS STUDY AIMED TO INVESTIGATE THE RELATIONSHIP BETWEEN THE TELOMERASE ACTIVITY AND GROWTH RATE OF HUCMSCS AT DIFFERENT PASSAGES...

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