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Information Seminar Paper

Title

EFFECT OF BRI2 BRICHOS DOMAIN ON THE α-SYNUCLEIN AGGREGATION

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Abstract

 INTRODUCTION: AMYLOID DISEASES SUCH AS ALZHEIMER, PARKINSON, AND PRION DISEASE ARE ASSOCIATED WITH A SPECIFIC FORM OF PROTEIN MISFOLDING AND AGGREGATION INTO OLIGOMERS AND FIBRILS RICH IN B- SHEET STRUCTURE. THE BRICHOS DOMAIN CONSISTING OF 100 RESIDUES IS FOUND IN MEMBRANE PROTEINS ASSOCIATED WITH DEGENERATIVE AND PROLIFERATIVE DISEASE, INCLUDING LUNG FIBROSIS (SURFACTANT PROTEIN…

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