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Title

P198- DIFFERENTIATION OF MSCS TO PANCREATIC β-CELLS FOR TRANSPLANTATION TO PATIENTS WITH DIABETES

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Abstract

 INTRODUCTION: DIABETES MELLITUS IS A METABOLIC DISEASE CAUSE BY GLUCOSE DYSREGULATION. DIABETES HAS TWO TYPES WITH THE DIFFERENT AGENTS. AUTOIMMUNE DEMOLITION OF PANCREATIC B- CELLS THAT PRODUCE INSULIN, RESULTS TYPE 1 DIABETES AND INSULIN RESISTANCE OF PERIPHERAL TISSUES CAUSES TYPE 2. IN TYPE 1, TRANSPLANTATION OF ISLET OR PANCREAS HAS AN ALTERNATIVE THERAPY, WHEN RECEIVE EXOGENOUS INSULIN. ISLET TRANSPLANTATION IS MORE USEFUL THAN WHOLE PANCREAS TRANSPLANTATION. WE EMPHASIZED THE ROLE OF MSCS IN THE REPAIR OF B CELL MASS AND FUNCTION AND WE DESCRIBED THE CAPACITY OF MSCS TO MODULATE THE AUTOIMMUNE RESPONSE DURING THE PATHOGENESIS OF DIABETES MELLITUS...

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