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Title

P190- CHRONIC MYELOID LEUKEMIA STEM CELLS, THE CANCER FATE IN THE HANDS OF MUSASHI AND NUMB

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Abstract

 INTRODUCTION: CHRONIC MYELOID LEUKEMIA (CML) IS A CLONAL MYELOPROLIFERATIVE DISORDER THAT IS CHARACTERIZED BY THE PRESENCE OF THE PHILADELPHIA CHROMOSOME. THE EXPRESSION OF THE BCR-ABL FUSION ONCOGENE PRODUCES A CONSTITUTIVELY ACTIVE TYROSINE KINASE RECRUITING AND ACTIVATING SEVERAL MOLECULAR PATHWAYS WHICH ULTIMATELY LEAD TO ABNORMAL CELLULAR ADHESION, ENHANCED PROLIFERATION AND INHIBITION OF APOPTOSIS...

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