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Title

P170- THE EFFECT OF GALECTIN-3 ON VIABILITY AND SPHEROID FORMATION OF HUMAN OVARIAN CANCER CELL LINE SKOV-3

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Abstract

 INTRODUCTION: GALECTIN-3 (GAL-3) BINDS TO CELL SURFACE CARBOHYDRATES AND INVOLVES IN VARIOUS PROCESSES SUCH AS PROLIFERATION, APOPTOSIS, CELL ADHESION, INVASION AND METASTASIS OF CANCER CELLS. DUE TO LATE DIAGNOSIS, OVARIAN CANCER IS THE DEATHLIEST CANCER AMONG WOMEN POPULATION. OVARIAN CANCER CELLS FORMS SECONDARY SPHEROID TUMORS THAT BINDS TO PERITONEUM AND PROMOTES OVARIAN CANCER METASTASIS. MOREOVER, SPHEROIDS MAY BE A SOURCE OF CANCER STEM CELLS (CSCS) WHICH HAS BEEN PROPOSED TO BE ASSOCIATED WITH CANCER RECURRENCE. THE PRESENT STUDY SOUGHT TO DETERMINE GAL-3 ROLE IN OVARIAN CANCER CELL SPHEROID FORMATION AND GROWTH/ VIABILITY...

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