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Information Seminar Paper

Title

FACTITIOUS AUTOMATED COMPLETE BLOOD COUNT (CBC) RESULTS DUE TO COLD AGGLUTINATION

Writers

MALEKI ALI

Pages

 Start Page | End Page

Abstract

 INTRODUCTION: THE ANALYSIS OF SPECIMENS, OBTAINED FROM PATIENTS WITH COLD AGGLUTININ DISEASES IS, IN GENERAL, A DIFFICULT PROBLEM FOR AUTOMATED HEMATOLOGY ANALYZERS. COLD AGGLUTININ DISEASES IS A FORM OF AUTOIMMUNE HEMOLYTIC ANEMIA CASED BY COLD-REACTING AUTOANTIBODIES. AUTOANTIBODIES THAT BIND TO ERYTHROCYTE MEMBRANE LEADING TO PREMATURE ERYTHROCYTE DESTRUCTION (HEMOLYSIS) CHARACTERIZE AUTOIMMUNE HEMOLYTIC ANEMIA. IN SUCH PATIENTS, BECAUSE OF AGGREGATION OF THE RBCS, WHICH OCCURS MAINLY AT TEMPERATURES LOWER THAN 30OC, IT IS NOT POSSIBLE TO MEASURE THE RBC COUNT AND HEMATOCRIT ACCURATELY.

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