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Information Seminar Paper

Title

ANTIOXIDANT AND CYTOTOXIC EFFECT OF AQUEOUS AND HYDROALCOLI EXTRACT OF THE ACHILLEAMILLEFOLIUM L. ON MCF-7 CELL LINE

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Abstract

 BACKGROUND: THE AIM OF THIS STUDY WAS TO EVALUATE THE ANTIOXIDANT AND ANTI-PROLIFERATIVE POTENTIAL OF ACHILLEA MILLEFOLIUM L. MATERIALS AND METHODS: THE ANTIOXIDANT ACTIVITY OF THE AQUEOUS AND HYDROALCHOLIC EXTRACT OF ACHILLEA MILLE FOLIUM L. LEAF AND FLOWER WAS MEASURED BY DPPH AND FRAP METHOD WHILE ITS ANTI-PROLIFERATIVE ACTIVITY ON HUMAN BREAST CANCER CELL LINE (MCF-7) WAS EVALUATED USING MTT ASSAY.RESULTS: THE ETHANOLIC EXTRACT OF THE LEAF AND THE METHANOLIC EXTRACT OF THE FLOWER HAD THE HIGHEST RADICAL SCAVENGING ACTIVITY AND FERRIC ION REDUCING ACTIVITIES. A TIME AND DOSE-DEPENDENT CYTOTOXIC EFFECTS OF DIFFERENT EXTRACT WAS OBSERVED ON MCF-7 CELLS. THE DIFFERENCE IN CELL VIABILITY BETWEEN HYDROALCHOLIC (METHANOL AND ETHANOL) AND AQUEOUS EXTRACTS OF LEAF AND FLOWER WAS SIGNIFICANT (P<0.05).

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