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Information Seminar Paper

Title

PAROXETINE ATTENUATES BOTH THE DEVELOPMENT AND EXISTING NEUROPATHIC PAIN IN A RAT MODEL OF NEUROPATHY

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Abstract

 INTRODUCTION: P2X4 RECEPTOR IN ACTIVATED MICROGLIA PLAYS A KEY ROLE IN THE PATHOGENESIS OF NEUROPATHIC PAIN. SPINAL NERVE INJURY INDUCES UP REGULATION OF P2X4 RECEPTORS ON ACTIVATED MICROGLIA IN THE SPINAL CORD AND BLOCKADE OF P2X4 RECEPTORS CAN REDUCE NEUROPATHIC PAIN

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