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Information Seminar Paper

Title

EFFECTS OF THE CUMIN CYMINUM L. PLUS LIME ON WEIGHT LOSS AND METABOLIC STATUS IN OVERWEIGHT SUBJECTS: A RANDOMIZED DOUBLE-BLIND PLACEBO CONTROLLED CLINICAL TRIAL

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Abstract

 INTRODUCTION: TO THE BEST OF OUR KNOWLEDGE, THIS IS THE FIRST STUDY EVALUATING THE BENEFICIAL EFFECTS OF CUMIN CYMINUM L. AND LIME CO-ADMINISTRATION ON WEIGHT LOSS, MARKERS OF INSULIN METABOLISM, LIPID PROFILES AND BIOMARKERS OF OXIDATIVE STRESS AMONG OVERWEIGHT SUBJECTS. THE CURRENT STUDY WAS CARRY OUT TO ASSESS THE EFFECTS OF COMBINED CUMIN CYMINUM L. AND LIME ADMINISTRATION ON WEIGHT LOSS AND METABOLIC PROFILES AMONG OVERWEIGHT SUBJECTS.METHODS: THIS RANDOMIZED DOUBLE-BLIND PLACEBO-CONTROLLED CLINICAL TRIAL WAS DONE AMONG 72 OVERWEIGHT SUBJECTS, AGED 18-60 YEARS OLD. PARTICIPANTS WERE RANDOMLY DIVIDED INTO THREE GROUPS. GROUP A RECEIVED HIGH-DOSE CUMIN CYMINUM L. AND LIME CAPSULES (75 MG EACH, N=24), GROUP B LOW-DOSE CUMIN CYMINUM L. AND LIME CAPSULES (25 MG EACH, N=24) AND GROUP C PLACEBOS (N=24) TWICE DAILY FOR 8 WEEKS. FASTING BLOOD SAMPLES WERE TAKEN AT BASELINE AND END-POINT THE INTERVENTION TO DETERMINE MARKERS OF INSULIN METABOLISM, LIPID CONCENTRATIONS AND BIOMARKERS OF OXIDATIVE STRESS.RESULTS: AFTER 8 WEEKS FOLLOW UP, TAKING HIGH-DOSE CUMINUM CYMINUM L. PLUS LIME CAPSULES HAS RESULTED IN SIGNIFICANT DECREASES IN WEIGHT (-2.1±1.7 VS. -1.2±1.5 AND +0.2±1.3 KG, RESPECTIVELY, P<0.001) AND BMI (-0.8±0.6 VS. -0.5±0.5 AND +0.1±0.5 KG/M2, RESPECTIVELY, P<0.001) COMPARED WITH LOW-DOSE CUMINUM CYMINUM L. PLUS LIME AND PLACEBO. IN ADDITION, HIGH-DOSE CUMINUM CYMINUM L. AND LIME CO-ADMINISTRATION COMPARED WITH LOW-DOSE CUMINUM CYMINUM L. PLUS LIME AND PLACEBO, LED TO A SIGNIFICANT REDUCTION IN FASTING PLASMA GLUCOSE (FPG) (-20.9±25.5 VS. -7.8±16.8 AND +4.6±14.3 MG/DL, RESPECTIVELY, P<0.001) AND A SIGNIFICANT RISE IN QUANTITATIVE INSULIN SENSITIVITY CHECK INDEX (QUICKI) (+0.02±0.02 VS. +0.01±0.02 AND -0.01±0.01, RESPECTIVELY, P=0.008). ADDITIONALLY, SIGNIFICANT DECREASES IN SERUM TRIGLYCERIDES (-14.1±56.2 VS. +13.9±36.8 AND +10.6±25.1 MG/DL, RESPECTIVELY, P=0.03), TOTAL- (-18.4±28.6 VS. +8.6±28.5 AND -1.0±24.8 MG/DL, RESPECTIVELY, P=0.004) AND LDL-CHOLESTEROL LEVELS (-11.8±20.7 VS. +6.5±23.2 AND -2.9±20.4 MG/DL, RESPECTIVELY, P=0.01) WERE OBSERVED FOLLOWING THE CONSUMPTION OF HIGH-DOSE CUMINUM CYMINUM L. PLUS LIME COMPARED WITH LOW-DOSE CUMINUM CYMINUM L. PLUS LIME AND PLACEBO.CONCLUSION: TAKEN TOGETHER, THE FINDINGS OF THE CURRENT STUDY INDICATED THAT TAKING HIGH-DOSE CUMIN CYMINUM L. PLUS LIME FOR 8-WEEK AMONG OVERWEIGHT SUBJECTS HAD BENEFICIAL EFFECTS ON WEIGHT, BMI, FPG, QUICKI, TRIGLYCERIDES, TOTAL- AND LDL-CHOLESTEROL LEVELS.

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