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Information Seminar Paper

Title

THE EFFECT OF A 8 WEEK EXERCISE ON PENTYLENETETRAZOLE KINDLED RATS

Writers

RADMANESH M.

Pages

 Start Page | End Page

Keywords

PTZ 
RAT 

Abstract

 INTRODUCTION: REGULAR PHYSICAL ACTIVITY HAS MANY BENEFITS FOR MENTAL AND PHYSICAL CONDITION BUT ITS IMPLICATIONS FOR EPILEPSY ARE STILL CONTROVERSIAL, THE AIM OF THIS STUDY IS EXAMINATION OF THE EFFECT OF 8 WEEK EXERCISE ON PENTYLENETETRAZOLE (PTZ) KINDLED SEIZURES IN RATS.METHODS: IN THIS EXPERIMENTAL STUDY, 20 ADULT MALE WISTAR RATS WERE RANDOMLY DIVIDED INTO TWO EQUAL GROUPS. . EACH OF THE GROUPS RECEIVED INJECTIONS OF PTZ TO BE KINDLED. THEN, FOR 6 WEEKS, THE EXPERIMENTAL GROUP EXERCISED AND THE CONTROL GROUP(WERE EPILEPTIC WITHOUT EXERCISE) RESTED. 24 HOURS AFTER THIS PERIOD, THE PTZ LAST INJECTED TO BOTH GROUPS AND SEIZURE PARAMETERS IN BOTH GROUPS WERE COMPARED WITH PENULTIMATE INJECTION (BEFORE TREATMENT). FOR DATA ANALYSIS WAS USED FROM ANOVA AND TUKEY TEST AT SIGNIFICANCE LEVEL OF P<0.05.RESULTS: IN KINDLED MICES WITH THE EXERCISE, S2L AND S4L INCREASED SIGNIFICANTLY THAN INJECT THE PENULTIMATE (P< 0.001). ALSO, THESE TWO PARAMETERS INCREASED SIGNIFICANTLY IN COMPARISON WITH LAST INJECTION OF THE CONTROL GROUP (P< 0.001). S5D, SD IN KINDLED MICES WITH THE EXERCISE REDUCED SIGNIFICANTLY THAN PENULTIMATE INJECTION (P< 0.001). ALSO, THESE TWO PARAMETERS INCREASED SIGNIFICANTLY IN COMPARISON WITH LAST INJECTION OF THE CONTROL GROUP (P< 0.01).CONCLUSION: THE RESULTS SHOWED THAT EXERCISE 6 WEEKS REDUCED THE SEVERITY OF PTZ-INDUCED SEIZURE IN RATS.

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