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Information Seminar Paper

Title

MICRORNA-146A EXPRESSION AND ITS INTERVENTION FOR NF-КB SIGNALING PATHWAY IN DIABETIC RAT AORTA

Writers

SALEH M. | ATIQUZZAMAN M.

Pages

 Start Page | End Page

Abstract

 INTRODUCTION: THE PRESENT STUDY WAS DESIGNED TO EVALUATE WHETHER MICRORNA-146A, AS AN NF-КB REGULATING FACTOR AND ITS ADAPTER PROTEINS (TRAF6 AND IRAK1), ARE AFFECTED BY DIABETES IN RAT AORTA.METHODS: MALE WISTAR RATS WERE RANDOMLY DIVIDED INTO CONTROL AND DIABETIC GROUPS (N=6 IN EACH). DIABETES WAS INDUCED BY A SINGLE INJECTION OF STREPTOZOTOCIN (55 MG/KG; I.P.) IN 12 H FASTED RATS. THE GENE EXPRESSION OF MICRORNA-146A, NF-ΚB, IRAK1, AND TRAF6 WERE DETERMINED BY REAL TIME PCR.RESULTS: THE EXPRESSION OF MICRORNA-146A WAS DOWN-REGULATED IN DIABETIC AORTA WHEN COMPARED WITH THE CONTROL GROUP (P<0.05). THE MRNA EXPRESSION LEVELS OF NF-КB, TRAF6 AND IRAK1 ALSO INCREASED IN THE DIABETIC RAT AORTA WHEN COMPARED WITH THEIR CONTROL COUNTERPARTS (P<0.01 FOR ALL COMPARISONS).CONCLUSION: THESE RESULTS SUGGEST THAT DOWN-REGULATION OF MICRORNA-146A MAY LEAD TO DERANGEMENT IN NF-КB NEGATIVE FEEDBACK LOOP, PROPELLING THE AORTA TOWARD INFLAMMATION.

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