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Information Seminar Paper

Title

EFFECT OF PROXISOME PROLIFERATOR-ACTIVATED RECEPTORS AGONISTS ON SERUM INFLAMMATORY MARKERS IN DIABETIC RATS

Writers

PISHDAD G.R.

Pages

 Start Page | End Page

Abstract

 INTRODUCTION: INFLAMMATION HAD A KEY ROLE IN SEVERAL PATHOLOGICAL CONDITIONS INCLUDING ATHEROSCLEROSIS. PREVIOUS STUDIES INDICATED THAT THE PROXISOME PROLIFERATOR-ACTIVATED RECEPTORS (PPAR) ARE INVOLVED IN NUMEROUS PHYSIOLOGICAL AND PATHOLOGICAL CONDITIONS. THE AIM OF THIS STUDY WAS TO INVESTIGATE THE EFFECT OF PPAR AGONISTS INCLUDING PPARΑ (FENOFIBRATE), PPARG/D (GW0742), PPARG (ROSIGLITAZONE) AND PAN PPAR (BEZAFIBRATE) ADMINISTRATION ON SERUM HIGH-SENSITIVE C-REACTIVE PROTEIN (HSCRP) AND INTERLEUKINE-6 (IL-6) IN MALE DIABETIC RATS.METHODS: THE MALE WISTAR RATS WERE RECEIVED STREPTOZOTOCIN FOR INDUCTION OF TYPE I DIABETES. THEN, THEY WERE RANDOMLY DIVIDED INTO FIVE GROUPS: DIABETIC, DIABETIC+FENOFIBRATE (100 MG/KG/DAY; GAVAGE), DIABETIC+GW0742 (1 MG/KG/DAY, SC), DIABETIC+ROSIGLITAZONE (8 MG/KG/DAY; GAVAGE) AND DIABETIC+BEZAFIBRATE (400 MG/KG/DAY; GAVAGE). AFTER 21 DAY, THE SERUM LEVELS OF HSCRP AND IL-6 WERE MEASURED BY ELISA KITS.RESULTS: THE RESULTS SHOWED THAT ADMINISTRATION OF DIFFERENT PPAR AGONISTS DID NOT ALTER SERUM HSCRP AND IL-6 CONCENTRATIONS IN DIABETIC ANIMALS.CONCLUSION: IT SEEMS THAT CHANGES OF SERUM INFLAMMATORY MARKERS ARE NOT RESPONSIBLE FOR EFFECTS OF PPARS AGONIST IN ATHEROSCLEROSIS PROCESS AND THE OTHER MECHANISMS SHOULD BE STUDIED.

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