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Information Seminar Paper

Title

RENO PROTECTIVE EFFECTS OF ALISKIREN, ERBESARTAN AND RAMIPRIL IN DIABETIC NEPHROBATHY IN RATS

Writers

TASHAYOD M.

Pages

 Start Page | End Page

Abstract

 INTRODUCTION: DIABETIC NEPHROPATHY IS AN INSIDIOUS AND LETHAL CVOMPLICATION OF DIABETES MELLITUS. THE RENIN ANGIOTENSIN SYSTEM HAS BEEN PROPOSED AS A KEY STRATEGY FOR REDUCING KIDNEY DAMAGE. THIS STUDY WAS DESIGNED TO COMPARE THE EFFECTIVENESS OF DIFFERENT ANGIOTENSIN INHIBITORS, DIRECT RENNIN INHIBITOR (ALISKIREN), ANGIOTENSIN-CONVERTING ENZYME INHIBITORS (RAMIPRIL) AND ANGIOTENSIN II RECEPTOR BLOCKER (IRBESARTAN) IN PREVENTION AND TREATMENT OF NEPHROPATHY IN A GROUP OF RAT INDUCED DIABETES.METHODS: THIRTY RATS WERE DIVIDED INTO TWO GROUPS. THE FIRST GROUP CONSISTED OF 6 RATS WHICH WERE CONSIDERED AS THE NORMAL CONTROL GROUP. THE SECOND GROUP INCLUDED 24 ALLOXAN INDUCED DIABETIC RATS. THE DIABETIC MODEL RATS WERE SUBDIVIDED INTO FOUR SUBGROUPS OF SIX RATS EACH. THE FIRST SUBGROUP SERVED AS A POSITIVE CONTROL. THE SECOND, THIRD AND FOURTH SUBGROUP RECEIVED RAMIPRIL, IRBESARTAN AND ALISKIREN RESPECTIVELY.RESULTS: DIABETIC NEPHROPATHIC RATS SHOWED A SIGNIFICANT INCREASE IN BLOOD GLUCOSE LEVEL, BLOOD PRESSURE, HEART RATE, SERUM UREA, SERUM CREATININE, IN ADDITION TO DETERIORATING RENAL FUNCTIONS INCLUDING (URINE FLOW, GLOMERULAR FILTRATION RATE, URINARY NA+ AND K+ EXCRETION RATE, ALBUMIN AND CREATININE IN THE URINE). THE ADMINISTRATION OF RAMIPRIL, IRBESARTAN, AND ALISKIREN CAUSED A SIGNIFICANT REDUCTION IN BLOOD PRESSURE, BLOOD GLUCOSE, SERUM UREA, NA+ AND K+ EXCRETION RATE, WITH A SIGNIFICANT IMPROVEMENT IN URINE FLOW AND GLOMERULAR FILTRATION RATE. ALL THREE DRUGS INDUCED A SIGNIFICANT ELEVATION IN SERUM K+ CONCENTRATION.CONCLUSION: ADMINISTRATION OF DIFFERENT ANGIOTENSIN INHIBITORS (RAMIPRIL, IRBESARTAN, & ALISKIREN) COULD SLOW THE PROGRESSION OF NEPHROPATHY IN ALLOXAN INDUCED DIABETIC RATS. BOTH RAMIPRIL AND IRBESARTAN HAD THE SAME RENO PROTECTIVE EFFECTS FOR MOST PARAMETERS.

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