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Information Seminar Paper

Title

THE ASSOCIATION BETWEEN SERUM NITRIC OXIDE METABOLITES AND INSULIN LEVEL AND INSULIN RESISTANCE INDICES AMONG THE IRANIAN ADULTS

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Abstract

 INTRODUCTION: IT HAS BEEN SUGGESTED THAT INSULIN RESISTANCE IS ASSOCIATED WITH ALTERED NITRIC OXIDE (NO) HOMEOSTASIS. SINCE THERE IS NO POPULATION-BASED STUDY REPORTING THE ASSOCIATION BETWEEN FASTING SERUM INSULIN AND NO METABOLITE (NOX) VALUES WITH MULTIVARIABLE ADJUSTMENT, THIS STUDY IS DESIGNED TO DETERMINE THE ASSOCIATION BETWEEN SERUM NOX AND FASTING INSULIN LEVELS AND INSULIN RESISTANCE/SENSITIVITY INDICES IN A SAMPLE OF A POPULATION BASED STUDY IN IRAN.METHODS: THIS STUDY WAS PERFORMED WITHIN THE FRAMEWORK OF TEHRAN LIPID AND GLUCOSE STUDY (TLGS). THE DATA OF 1518 NON-DIABETIC SUBJECTS (955 WOMEN, AGE 20–87 YEARS) PARTICIPATED IN THE PHASE III OF THE TEHRAN LIPID AND GLUCOSE STUDY (2006-2008) WERE ANALYZED. SERUM NOX CONCENTRATION WAS MEASURED USING GRIESS METHOD. FASTING SERUM INSULIN WAS DETERMINED BY THE ELECTROCHEMILUMINESCENCE IMMUNOASAAY (ECLIA) METHOD. MULTIPLE REGRESSION ANALYSIS WAS USED TO DETERMINE THE ASSOCIATION BETWEEN SERUM NOX CONCENTRATIONS AND QUARTILES OF INSULIN AND INSULIN RESISTANCE/SENSITIVITY INDICES (HOMA1-IR, HOMA2-IR, AND QUICKI).RESULTS: AMONG THE WOMEN, NOX CONCENTRATION WAS SIGNIFICANTLY CORRELATED WITH HOMA1- IR AND QUICKI (P<0.05) AND ITS CORRELATION WITH INSULIN AND HOMA2-IR WAS MARGINALLY SIGNIFICANT (P=0.057 AND P=0.053, RESPECTIVELY). NO SIGNIFICANT CORRELATION WAS OBSERVED AMONG THE MEN (P>0.05). NOX CONCENTRATIONS DIFFERED SIGNIFICANTLY BETWEEN THE QUARTILES OF INSULIN AND INSULIN RESISTANCE/SENSITIVITY INDICES AMONG WOMEN AND THE TOTAL POPULATION (P<0.05), WHICH REMAINED SIGNIFICANT AFTER AGE ADJUSTMENT (P<0.05), BUT NOT AFTER MULTIVARIABLE ADJUSTMENT (P>0.05).CONCLUSION: FASTING INSULIN LEVEL AND INSULIN RESISTANCE/SENSITIVITY INDICES ARE NOT ASSOCIATED WITH SERUM NOX LEVELS AFTER MULTIVARIABLE ADJUSTMENT.

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