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Information Seminar Paper

Title

CHANGES IN PROINFLAMMATORY AND ANTI-INFLAMMATORY CYTOKINES FOLLOWING TRAUMATIC BRAIN INJURY: NOVEL ROLES FOR ESTROGEN RECEPTORS Α AND β

Writers

VAEZ ZADEH S.A.

Pages

 Start Page | End Page

Abstract

 INTRODUCTION: TRAUMATIC BRAIN INJURY (TBI) IS A MAJOR CAUSE OF DEATH IN WORLDWIDE AND CLINICAL STUDIES SUGGESTS THAT BRAIN EDEMA (INFLAMMATION) AND CORTICAL CONTUSION DUE TO TBIOCCUR LESS IN FEMALES. 17B-ESTRADIOL (E2) EXHIBITS ANTI-INFLAMMATORY PROPERTIES. IN THIS STUDY THE EFFECTS OF ESTROGEN RECEPTORS (ERS) AGONISTS AS REGULATORS OF CNS CYTOKINES LEVELS AND NEUROINFLAMMATION AFTER TBI WERE EVALUATED.METHODS: BRAIN LEVELS OF PROINFLAMMATORY (IL-1B, IL-6, AND TNF-A) AND ANTI-INFLAMMATORY (IL-10 AND IL-1RA) CYTOKINES WERE QUANTIFIED IN THE OVARIECTOMIZED RATS 24 H AFTER TBI INDUCED BY MARMAROU’S METHOD. ANIMALS WERE TREATED WITH DOSES OF ER-Α AGONIST (PPT) AND ER-B AGONIST (DPN) 24 H AFTER THE TBI.RESULTS: RESULTS REVEALED THAT, THERE WAS A SIGNIFICANT INCREASE OF IL-1B, IL-6, AND TNF-A AT 24 H AFTER TBI, AND THAT PPT, DPN OR PPT+DPN DECREASED BRAIN LEVELS OF THESE PROINFLAMMATORY CYTOKINES. THE BRAIN LEVELS OF IL-10 AND IL-1RA IN OVARIECTOMIZED RATS SIGNIFICANTY DECREASED AT 24 H AFTER TBI, BUT THE BRAIN LEVELS OF THESE ANTI-INFLAMMATORY CYTOKINES INCREASED FOLLOWING ADMINISTRATION OF PPT, DPN OR PPT+DPN.CONCLUSION: TAKEN TOGETHER, THESE STUDIES IDENTIFIED A DRAMATIC CYTOKINE-MEDIATED NEUROINFLAMMATORY RESPONSE THAT IS REGULATED THROUGH BOTH ER-A AND ER-B RECEPTORS. THIS MAY SUGGEST A THERAPEUTIC POTENTIAL IN THE BRAIN TRAUMA FOR ER-SPECIFIC AGONISTS.

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