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Information Seminar Paper

Title

VASODILATORY RECEPTORS OF RENNIN – ANGIOTENSIN SYSTEM (AT2 & MAS) IN RENAL BLOOD FLOW RESPOND TO ANGIOTENSIN II: DOES THESE RECEPTORS ACTIVITY RELATED TO FEMALE SEXUAL HORMONE?

Writers

PARSAFAR G. | KESHAVARZI E.

Pages

 Start Page | End Page

Keywords

RENINE ANGIOTENSIN SYSTEM (RAS) 

Abstract

 INTRODUCTION: EPIDEMIOLOGIC STUDIES SHOWN THAT THE PROGRESSION OF RENAL DISEASE IN MALE GREATER THAN FEMALE. THE EXACT MECHANISMS ARE NOT WELL UNDERSTOOD, BUT IT IS CLEAR THAT RAS PLAY DIFFERENT ROLES IN BOTH MALE AND FEMALE GENDERS. IN CURRENT STUDY, WE WERE GOING TO EXAMINE THE EFFECT OF MASR AND AT2R IN TWO GENDERS AND THEIR INTERACTION IN RESPONSE TO ANGIOTENSIN II (ANGII) AND ANG1-7 INFUSION IN RAT ANIMAL MODEL.METHODS: THIS STUDY WAS ASSIGNED INTO FOUR PHASES. MALE AND FEMALE WISTAR RATS WERE RANDOMLY ASSIGNED TO: FIRST PHASE, ANIMALS DIVIDED TO 2 GROUPS (MALE AND FEMALES) EACH OF GROUP RECEIVED VEHICLE AND MASR ANTAGONIST (A779) + ANGII (30, 100, 300, 1000 NG/KG/MIN).SECOND PHASE, ANIMALS DIVIDED TO 2 GROUPS (MALE AND FEMALES) EACH OF GROUP RECEIVED VEHICLE AND A779+AT2R ANTAGONIST (PD123319) + ANGII (30, 100, 300, 1000 NG/KG/MIN).THIRD PHASE, FEMALE RATS WERE DIVIDED TO THREE GROUPS INCLUDING INTACT, OVAREICTOMIZED THAT RECEIVED PLACEBO (OVX) AND OVARECTOMIZED + ESTROGEN (OVE)). EACH OF THE GROUPS RECEIVED VEHICLE AND PD123319 +ANGII (30, 100, 300, 1000 NG/KG/MIN). FOURTH PHASE, ANIMALS DIVIDED TO 2 GROUPS (MALE AND FEMALES) EACH OF GROUP RECEIVED VEHICLE AND A779AND + ANG1-7(100, 300, 1000 NG/KG/MIN). AFTER ANESTHETIZING, LEFT COMMON CAROTID AND FEMORAL ARTERIES AND JUGULAR VEIN WERE CHATHERIZED. RBF MEASURED DIRECTLY.RESULTS: IN THE FIRST AND SECOND PHASES, IN FEMALE RATS, A779+PD123319 DECREASED RESPONSE TO ANGII SIGNIFICANTLY (P<0.05).IN THE THIRD PHASE:IN OVE GROUP IN PRESENCE OF PD123319 RESPONSE TO ANGII WAS SIGNIFICANTLY ATTENUATED (P<0.05).IN FORTH PHASE: IN ALL OF GROUPS RBF INCREASED IN RESPONSE TO ANG1-7 BUT IN FEMALE RATS THIS INCREASING WAS SIGNIFICANT (P<0.05).CONCLUSION: IT IS CONCLUDED THAT MASR REGULATES RENAL HEMODYNAMIC CONDITION WITH GREATER EFFECTS IN FEMALE THAN MALE.

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