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Title

INVESTIGATION OF INCLUSION COMPLEX OF β -CYCLODEXTRIN WITH PHENYLEPHRINE

Writers

KHALAFI L. | RAFIEE M. | KARIMI J.

Pages

 Start Page | End Page

Abstract

 INTRODUCTION: NOWADAYS CYCLODEXTRINS KNOWN AS THE MOST SUCCESSFUL GROUP OF MACROCYCLIC COMPOUNDS WITHIN THE FIELD OF SUPRAMOLECULAR CHEMISTRY. THEY HAVE A UNIQUE ABILITY TO FORM INCLUSION COMPLEXES WITH WIDE VARIETY OF MOLECULES. THE COMPLEXATION OF THE GUEST MOLECULE CAN EFFECTIVELY CHANGE ITS CHEMICAL OR PHYSICAL PROPERTIES [1]. PHENYLEPHRINE (PEP) IS A SELECTIVE A1-ADRENERGIC RECEPTOR AGONIST USED PRIMARILY AS A DECONGESTANT, AS AN AGENT TO DILATE THE PUPIL, AND TO INCREASE BLOOD PRESSURE. PEP IS USED AS A DECONGESTANT SOLD AS AN ORAL MEDICINE, AS A NASAL SPRAY, OR AS EYE DROPS [2]. IN THIS WORK THE ACID-BASE EQUILIBRIUM OF PEP IS STUDIED IN THE ABSENCE AND PRESENCE OF B-CYCLODEXTRIN (B -CD).

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