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Title

ELECTROCHEMICAL BEHAVIOR AND DETERMINATION OF SELEGILINE ON THE SURFACE OF CARBON PASTE ELECTRODE MODIFIED BY NICKEL NANOPARTICLES

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Abstract

 INTRODUCTION: SELEGILINE IS A SELECTIVE INHIBITOR OF THE MONOAMINE OXIDASE (MAO) ENZYME. SINCE SELEGILINE HAS A GREATER AFFINITY FOR TYPE B THAN TYPE A MAO IT CAN SERVE AS A SELECTIVE INHIBITOR OF MAOB IF IT IS ADMINISTERED AT THE RECOMMENDED DOSE. IT ALSO INHIBITS THE RE-UPTAKE OF DOPAMINE INTO NERVE TERMINALS AND BLOCKS PRESYNAPTIC DOPAMINE RECEPTORS WHICH MAY INCREASE DOPAMINERIC ACTIVITY IN THE BRAIN [1].

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