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Information Seminar Paper

Title

PRODUCTION OF PIOGLITAZONE HYDROCHLORIDE FINEPARTICLES BY SUPERCRITICAL ANTI-SOLVENT (SAS)

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 Start Page | End Page

Abstract

 THE PURPOSE OF THIS RESEARCH WAS TO EVALUATE THE EFFECTS OF SUPERCRITICAL PRECIPITATION ON THE PHYSICOCHEMICAL CHARACTERISTICS OF PIOGLITAZONE HYDROCHLORIDE (PG). THEREFORE, PG POWDER WAS DISSOLVED IN BINARY MIXTURES OF METHANOL, ETHANOL, ACETONE, DICHLOROMETHAN AND THE SOLUTIONS WERE SPRAYED INTO THE SUPERCRITICAL CARBON DIOXIDE. THE PROCESSED POWDERS WERE HARVESTED AND ANALYZED BY USING SCANNING ELECTRONE MICROSCOPY (SEM) AND DIFFERENTIAL SCANNING CALORIMETERY METHODS (DSC). DIFFERENT MORPHOLOGIES OF PG PARTICLES WERE OBSERVED IN THE SEM MICROGRAPHS AND THE PARTICLE SIZES VARIED BETWEEN 37.1-95.1 MM. THE DSC THERMOGRAMS CONFIRMED THE SIMILAR THERMAL BEHAVIOR BEFORE AND AFTER PROCESS. THE DISSOLUTION-RATE OF UNPROCESSED AND PROCESSED POWDERS WAS COMPARED AND SHOWED ENHANCEMENT IN THE DISSOLUTION RATE OF PROCESSED POWDERS UP TO 2 TIMES.

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