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Title

ONE-POT SOLVENT-FREE RAPID AND GREEN SYNTHESIS OF DERIVATIVE 3-AMINO-4-PHENYL-4HCHROMENE-2-CARBONITRILE USING GRINDSTONE CHEMISTRY

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Abstract

 AN EASY SOLVENT-FREE METHOD IS DESCRIBED FOR THE SYNTHESIS OF DERIVATIVE 3-AMINO-4- PHENYL-4H-CHROMENE-2-CARBONITRILE BY A ONE POT THREE COMPONENT COUPLING REACTION OF AROMATIC ALDEHYDES, MALONONITRILE, AND PHENOL USING 1,4-DIAZABICYCLO[2.2.2]OCTANE (DABCO)AS THE CATALYST BY GRINDSTONE CHEMISTRY. THE SALIENT FEATURES OF THIS ONE POT PROTOCOL ARE SHORT REACTION TIMES, CLEANER REACTION PROFILES AND SIMPLE WORKUP [1-3].

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