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Title

FABRICATION OF AN ELECTROCHEMICAL SENSOR BASED ON COMPUTATIONALLY DESIGNED MOLECULARLY IMPRINTED POLYMERS FOR DETERMINATION OF MESALAMINE IN REAL SAMPLES

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Abstract

 A NOVEL ELECTROCHEMICAL SENSOR BASED ON MESALAMINE (MESAL) MOLECULARLY IMPRINTED POLYMER (MIP) FILM ON A GLASSY CARBON ELECTRODE WAS FABRICATED. THIS FILM WAS CAST ON GLASSY CARBON ELECTRODE BY ELECTROCHEMICAL POLYMERIZATION IN SOLUTION OF O-PHENYLENEDIAMINE (OP), GALLIC ACID (GA), P-AMINOBENZOIC ACID (ABA) AND TEMPLATE MESALAMINE VIA CYCLIC VOLTAMMETRY SCANS AND FURTHER DEPOSITION OF AG NANOPARTICLES (AG NPS) [1]. DENSITY FUNCTIONAL THEORY (DFT) WAS DEVELOPED TO STUDY THE INTERMOLECULAR INTERACTIONS IN THE POLYMERIZATION MIXTURE AND TO FIND SUITABLE FUNCTIONAL MONOMERS IN MIP PREPARATION. DFT RESULTS SHOW THAT SPIN MULTIPLICITY OF ELECTRONIC GROUND STATE MESALAMINE BEFORE AND AFTER COMPLEX FORMING WITH FUNCTIONAL MONOMERS OF OP, GA, ABA COMPOUNDS REMAIN SINGLET [2, 3]. THEORETICAL RESULT WITH DFT APPROACH WITH POLARIZABLE CONTINUUM MODEL AND ELECTROCHEMICAL EXPERIMENTAL RESULTS ARE AGREEMENT IN ALL CASES. THE SURFACE FEATURE OF THE ELECTRODE MODIFIED WITH AG NPS MOLECULARLY IMPRINTED POLYMER (AG NPS-MIP/GCE) WAS CHARACTERIZED BY CYCLIC VOLTAMMETRY (CV), SCANNING ELECTRON MICROSCOPIC (SEM) AND ELECTROCHEMICAL IMPEDANCE SPECTROSCOPY (EIS). UNDER THE OPTIMAL EXPERIMENTAL CONDITIONS, THE PEAK CURRENTS WERE PROPORTIONAL TO THE CONCENTRATIONS OF MESALAMINE IN THE RANGE, FROM 0.025 TO 100MM, WITH THE DETECTION LIMIT OF 0.015 MM. DUE TO THE HIGH AFFINITY, SELECTIVITY AND STABILITY THE NANO AG IMPRINTED SENSOR PROVIDES A SIMPLE DETECTION PLATFORM FOR MESALAMINE REAL SAMPLES.

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