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Title

DRUGDELIVERY BY TITANIUM DIOXIDE NANOTUBES

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Abstract

 BACKGROUND: DRUG DELIVERY IS AN INTERDISCIPLINARY AND INDEPENDENT FIELD OF RESEARCH THAT IS GAINING THE ATTENTION OF PHARMACEUTICAL RESEARCHERS, MEDICAL DOCTORS AND INDUSTRY. A SAFE AND TARGETED DRUG DELIVERY COULD IMPROVE THE PERFORMANCE OF SOME CLASSIC MEDICINES ALREADY ON THE MARKET, AND MOREOVER, WILL HAVE IMPLICATIONS FOR THE DEVELOPMENT AND SUCCESS OF NEW THERAPEUTIC STRATEGIES SUCH AS ANTICANCER DRUG DELIVERY, PEPTIDE AND PROTEIN DELIVERY AND GENE THERAPY. NANOTUBES (NTS) HAVE BEEN DEVELOPED AS AN IMPORTANT STRATEGY TO DELIVER CONVENTIONAL DRUGS, RECOMBINANT PROTEINS, VACCINES AND MORE RECENTLY, DRUG-DELIVERY SYSTEMS MODIFY THE KINETICS, BODY DISTRIBUTION AND DRUG RELEASE OF AN ASSOCIATED DRUG.METHODS: TITANIUM DIOXIDE NANOTUBE ARRAYS (TNT) USED AS DRUG-CARRIES WAS PREPARED BY SELF-ORDERING ELECTROCHEMICAL ANODIZATION [1]. THE PREPARED TNT-TI SUBSTRATES WERE LOADED WITH DRUG VIA A SIMPLE METHOD, PUTTING DRUG SOLUTION AND DRYING IT [3]. DRUG-RELEASE EXPERIMENTS WITH THE MODEL ANTIBIOTIC CIPROFLOXACIN. SIGNIFICANT SURFACE-DEPENDENT DIFFERENCES IN THE RELEASE KINETICS OF CIPROFLOXACIN WERE OBSERVED. THE MORPHOLOGICAL AND CHEMICAL STRUCTURES OF TIO2 FILMS WERE CHARACTERIZED USINGSCANNING ELECTRON MICROSCOPY (SEM).THE AMOUNT OF THE DRUG WAS DETERMINED BY UV-VIS SPECTROSCOPY. THERE WAS A LINEAR RELATION BETWEEN ABSORPTION AND CONCENTRATION OF THE DRUG. ALL THE MEASURING WAS DETERMINED IN PBS (PHOSPHATE BUFFERED SALINE).RESULTS: THERE IS A RELATION BETWEEN DIAMETER AND LENGTH OF NANOTUBES AND VOLTAGE, TIME AND CONCENTRATION OF ELECTROLYTE. THE PARAMETERS OF THE NANOTUBES AFFECT ON THE RATE OF RELEASING OF THE DRUG.

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    APA: Copy

    ASADI, SOADA, EMAMALISABZI, REZA, & HADDADBAGHI, HABIBEH. (2014). DRUGDELIVERY BY TITANIUM DIOXIDE NANOTUBES. IRANIAN CHEMISTRY CONGRESS. SID. https://sid.ir/paper/910677/en

    Vancouver: Copy

    ASADI SOADA, EMAMALISABZI REZA, HADDADBAGHI HABIBEH. DRUGDELIVERY BY TITANIUM DIOXIDE NANOTUBES. 2014. Available from: https://sid.ir/paper/910677/en

    IEEE: Copy

    SOADA ASADI, REZA EMAMALISABZI, and HABIBEH HADDADBAGHI, “DRUGDELIVERY BY TITANIUM DIOXIDE NANOTUBES,” presented at the IRANIAN CHEMISTRY CONGRESS. 2014, [Online]. Available: https://sid.ir/paper/910677/en

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