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Information Seminar Paper

Title

THE INHIBITORY EFFECTS OF CHROZOPHORA TINCTORIA EXTRACT ON BENZOYL PEROXIDE AND ULTRA VIOLET-PROMOTED SKIN CARCINOGENESIS

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Abstract

 Environmental Radiations such as UV and chemicals have essential roles in cancer incidence. Usually Chemotherapy has a variety of side effects. In this study we attempt to evaluate the inhibitory effect of Chrozophora tinctoria on mouse skin tumors.Methods: Female Albino Swiss mice were divided in to four groups (each group 20 animals). Tumor initiation was acheved by a single topical application of 7,12-Dimethylbenze (a) anthracene (DMBA) (40mg/100 ml acetane/mouse). After 7 days, tumor promotion was begun by twice-weekly topical application of Benzoyl peroxide (BPO) (20 mg/300ml acetone/mouse) for a period of 32 weeks. Also before 4 hours of DMBA application groups 3 and 4 received a single topical dose of chrozophora tinctoria extract (10 mg/gr carbopol gel/mouse). During this period, the animals were observed for tumor incidence. Results: There were higher yields of tumors in those groups receiving DMBA + BPO and DMBA + BPO+ UV. However, the chrozophora tinctoria pretreated group showed significant inhibition in tumor incidence. The group of animals treated only with acetone, carbopol gel, DMBA, BPO and Chrozophora tinctoria alone did not develop any tumors during 32 weeks of observation.Conclusion: The results obtained from this study show that chrozophora tinctoria significantly inhibits Skin tumors, in comparison the control group. Our results also indicate that chrozophora tinctoria extract probably through the scavenging of free radicals plays an important role in skin cancer inhibition. However, the exact mechanism of tumor inhibition by chrozophora tinctoria remains elusive and needs further biochemicals/histopathological experimentations.

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