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Information Seminar Paper

Title

THE EFFECTS OF LITHIUM ON OVULATION AND FORMATION OF CORPUS LUTEUM IN WISTAR RAT

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Abstract

 Introduction: lithium which is used as an antidepression medicine is also important because of its inducing effects on canonical Wnt signaling pathway. Recent evidence have shown that this signaling pathway is involved in follicular development and formation of corpus luteum (CL). However these evidence are too little and also controversial. So in this project we investigated the effects of lithium, as an inducer of Wnt pathway on the ovulation and formation of CL.Methods: to address this question, immature 23 days wistar rat induced by PMSG (15 IU) and hCG (15 IU), were received IP injection of 250 mg/kg LiCl either co injection with hCG (exp. group 1) or 12h after hCG injection (exp. Group 2). Rats with only injection of PMSG and hCG were considered as control group. 24h after hCG injection, ovaries were removed and prepared for histological studies. Histological slides were examined for CL. In another experiment the ovulated eggs were counted in control and experimental group 1.Results: Results have shown that in exp. Group 1 in contrast with cont. group not only no CL was observed but also no eggs were collected in the oviduct. In exp. group 2 the number of mature CL were decreased however the number of immature CL were increased significantly compared to that of cont. group.Conclusion: Our results show that lithium is involved in mechanisms of ovulation and formation of CL possibly through its effect on Wnt signaling pathway.

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