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Information Seminar Paper

Title

ALTERED LEVELS OF PHOSPHORYLATED IGF-I RECEPTOR AND IGFBP-1 IN INSULIN RESISTANT ADULT RAT BRAIN

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Abstract

 Introduction: Two types of diabetes are known, type I as juvenile or insulin-dependent diabetes and type II as adult or non-insulin dependent diabetes. In type I the insulin producing beta cells of pancreas are completely destroyed and no more insulin is produced. In type II however, there is a problem in utilization of insulin and insulin resistance is therefore generated. Optional and indirect requirement of brain cells for insulin and on the contrary, the presence of insulin receptor in brain, the expression of insulin like growth factor I (IGF-1), its receptor and binding proteins (IGFBPs) made us to investigate any possible altered levels of the IGF-I system.Methods: To generate an insulin resistant animal model, young adult Wistar rats (150-200gr) were fed with plain or 10% fructose in their drinking water for two to three months.Results: Our immunohistochemical investigation of the brain tissues has shown that despite unchanged levels of insulin like growth factor I and its receptor, the levels of phosphorylated receptor and binding protein-1 (IGFBP-1) have been increased significantly in the insulin resistant rats in comparison with normal rats.Conclusion: Since low level of IGF-I in the serum of diabetic rats has been reported by other researchers, our observation regarding the increased level of binding protein which transfers IGF-I from blood to the brain followed by increased activity of IGF receptor can be considered as compensatory mechanisms for the maintenance of IGF function in brain.

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