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Information Seminar Paper

Title

IN-VITRO STUDY OF ANTI-PROLIFERATIVE AND ANTI-CARCINOGENIC EFFECTS OF FESELOL AND MOGOLTACIN ON EMBRYONAL CARCINOMA CELLS

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Abstract

 The pluripotent NTERA2 cells are classified as embryonal carcinoma (EC) cells and derived from human germ cell tumors. The proliferative potency of these cells is very high and they do not need feeder layer for culturing. In the present research the cytotoxic effects of Feselol and Mogoltacin, which are extracted from the Ferula badrakema (Apiaceae family), were investigated. the anti-proliferative /anti-carcinogenic effects of Feselol and Mogoltacin were evaluated by MTT assay, which is based on the functional feature of mitochondrial enzymes After determination of the growth curve of NTERA2 cells and the level of Oct4 mRNA, which is a marker of undifferentiated cells were determined.

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