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Title

STUDY OF LIVER RESISTANCE AGAINST TOXICITY INDUCED WITH DIFFERENT DOSES OF CARBON TETRACHLORIDE, BASED ON HISTOPATHOLOGIC EVIDENCES, IN BROILERS AT AGES 25 AND 40 DAYS (SUGESSTION OF BROILER LIVER AS A GOO MODEL FOR DETOXIFICATION MECHANISMS)

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Abstract

 Introduction: avians show more liver resistance against ccl4 as common hepatotoxin. Broilers based on the height growth rate and metabolism can be good models for toxicology researches. Methods: male broilers (Arian strain) at ages 40 and 25 days. Oral treatment with CCL4 0.5, 1, 2.5 cc/KgB.W (age 40 days); oral treatment with CCL4 2.5, 4 cc/KgB.W and i.p 2.5 cc/KgB.W (age 25 days). Inscription of daily weight gain, at the end of experiment we stained the liver samples by H.E and PAS for pathologic and glycogen changes.Results: Oral treatment with CCL4 0.5, 1, 2.5 cc/KgB.W (age 40 days); oral treatment with CCL4 2.5, 4 cc/KgB.W and i.p 2.5cc/KgB.W (age 25 days) induced no hepatotoxicity (lipid degenerative changes or necrosis in liver).Conclusion: It suggested that broilers have very strong detoxification system. Ever at young ages. Treatment with killer doses of this hepatotoxin in rat, in broilers only induced lower rate of growth .which may be induce as result of autoprotection and high tissue repair. we sugest the liver of broilers as a good model in toxiciligy researches for detoxification mechanisms.

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