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Information Seminar Paper

Title

CLINICAL AND HISTOLOGICAL STUDIES OF TOPICAL EFFECTS OF "RETINOIC ACID" ON DEVELOPMENT OF "BLASTEMA" TISSUE, IN "RABBIT PINNA PUNCH-HOLE" MODEL

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Abstract

 INTRODUCTION: "Belastema" tissue is a group of undifferentiated cells that are able to division and differentiation in some part of organism body. This cells are simillar to embryonic cells, in other word can mediated in development of organs and regeneration. Due to importance of "stem Cells" and because of study of regeneration; one of epimorfic examples in mammalians is belastema formation and then replacement of several types of basic tissues in the holes that generated in rabbit ears(Williams Boyce-1980). So blastema tissue in rabbits is applied model to study effects of teratogenic factors (Pfeiffer-1985).METHODS: In this study we examined he topical effects of "Retinoic Acid" in overdose to belastema regeneration and wound healing (Wei & Makori-1999). So we used white male newslandian rabbits that are 2.5 Kg in weghit and 6 month old. We generated 6 holes in one ear. So we had 9 sample for test and 9 sample for control totally. In test wound, is usd "Tretinoin" 1% cream, and in control wound we used base cream. RESULTS: The results indicate that topical usage of "Retinoic Acid" doesn't affect on regeneration speed, but only changes regeneration figure. In test cases didn't form the wound skin. This is very important to say that in all of test wounds after closing of hole there was an "Hypertrophic Scar". But there wasn't anything in control cases. Histological research and microscopic study show that retinoic acid affect on regeneration as a teratogen and increase cellular proliferation to generating Hypertrophic Scar. These results can refer the "Rabbit pinna punch hole" as a good model for teratogenic effects.

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