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Information Seminar Paper

Title

THE EFFECT OF ENALAPRIL ON INFLAMMATION AND IL-1β AND IL-8 PRODUCTION IN CHRONIC ARTHRITIS

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Abstract

  Introduction: Besides acting as a vasopressor hormone, angiotensin II (Ang II) has pro-inflammatory properties. Since angiotensin-converting enzyme, (ACE) is present in inflamed synovial membrane, in this study we investigated the effect of enalapril, in modulation of inflammation and cytokine production in experimentally induced chronic arthritis.Methods: Chronic joint inflammation was induced by antigen-induced arthritis method in rabbits. Enalapril was given orally (7.5mg/kg/day) two weeks before (prophylaxis group) or two weeks after (treatment group) the time of arthritis induction. Serum ACE activity was measured by HPLC. Concentrations of pro-inflammatory cytokines, IL-1b & IL-8 were measured in synovial fluid, and histology of knee joints was assessed in both groups.Results:  Data revealed that enalapril significantly reduced ACE activity in serum (P=0.004). It had no effect on synovial fluid concentration of IL-8 but significantly reduced the IL-1β production (P<0.05). Histology results revealed a significant reduction in villous hyperplasia and pannus formation (P<0.05 in both groups). In prophylaxis group no bone erosion was observed and the cartilage was either intact or slightly invaded by synoviocytes, while in non-treated group the cartilage was mostly invaded.Conclusion: It is concluded that enalapril reduces the production of pro-inflammatory cytokine IL-1b and severity of joint damage in chronic arthritis.

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