video

sound

Persian Version

View:

715

Download:

0

Cites:

Information Seminar Paper

Title

INDUCED PAW OEDEMA IN MALE RAT

Pages

 Start Page | End Page

Keywords

Not Registered.

Abstract

 Introduction: Inflammation respon is a body de se to the fensive endogenous and exogenous stimulators such as chemical, radiation, trauma and invasive microorganism, which result pain and tissue necrosis. The local symptoms of inflammation are calor,rubor,tumor and dolor. Today there are many natural and synthetic drugs for treatment of inflammation. Sodium valporate is an antiepileptic drug use particularly in the treatment of primary generalized seizure notably absence, myocolonic seizure, acute manic phase of bipolar disorder and for prophylaxis of migraine. The previous observation showed sodium valporate increase level of gamma amino butyric acid (GABA) in the central and peripheral nervous system. In acute inflammation, GABA showed a significant attenuation of paw oedema and nociception. Sodium valporate has other effects such as decrease of TNF, IL6, NO and reactive oxygen species, inhibition of histamine released by basophiles and can inhibit release of platelet-activating factor and activation of NF-kB (nuclear transcription factor kappa B).Methods: The aim of this study was evaluation of anti-inflammatory effect of sodium valporate .in order to evaluated the anti inflammatory and antiexudative of sodium valporate doses of 200,400 and 600 mg/kg were investigated on rat paw oedema that induced by carageenan.In addition, the plasma leakage in the inflamed tissue was evaluated by application of trypan blue as intravenous injection. Dexamethason was use as a positive control.Results: The result showed that sodium valporate doses of 400 and 600mg/kg decreased of inflammatory and exudative effect as compared to control group.Conclusion: It assumes that sodium valporate had peripheral anti-inflammatory effect which, mechanism probably is active of INF-kB and increase level of glucocorticoids hormone.

Cites

  • No record.
  • References

  • No record.
  • Related Journal Papers

  • No record.
  • Related Seminar Papers

  • No record.
  • Related Plans

  • No record.
  • Recommended Workshops






    File Not Exists.