video

sound

Persian Version

View:

1,300

Download:

0

Cites:

Information Seminar Paper

Title

THE ROLE OF NITRIC OXIDE-CYCLIC GMP PATHWAY IN MODULATION OF THE RAT OVARIAN STEROIDOGENESIS

Writers

Pages

 Start Page | End Page

Keywords

Not Registered.

Abstract

 Introduction: Nitric oxide (NO) is involved in a variety of biological phenomena, including the reproductive systems of male and female animals. The present study was designed to investigate the role of this potent mediator in the regulation of ovarian steroidogenesis in female rats.Methods: Twenty healthy, adult female rats (210±10 g) were divided into 4 groups and treated subcutaneously once daily for 21 successive days with either of the following chemicals: physiologic saline solution (control animals), L-NAME (an inhibitor of NO synthesis, 1 mg/kg), Trinitroglycerine (TNG, an NO donor, 2.5mg/kg), L-Arginine (L-Arg, the precursor of NO, 10mg/kg). On the day 22, the concentrations of progesterone and estradiol were measured by means of electro-chemiluminescence method.Results: Findings of the research work indicated that TNG decreased the concentration of progesterone significantly (by 50%, P<0.05). L-NAME treatment imposed a slight increased estradiol production.Conclusion: It is evident from the findings of our experiments that an overproduction of NO, resembled by NTG-related release of this substance, may dramatically decrease progesterone production and, hence, to cause sexual and reproductive dysfunction in female animals. It is suggested to perform a similar study in women receiving nitrovasodilators such as NTG to see whether or not such a phenomenon happens in human beings.

Cites

  • No record.
  • References

  • No record.
  • Related Journal Papers

  • No record.
  • Related Seminar Papers

  • No record.
  • Related Plans

  • No record.
  • Recommended Workshops






    File Not Exists.