video

sound

Persian Version

View:

650

Download:

0

Cites:

Information Seminar Paper

Title

EFFECT OF PAROXETINE ON OUABAIN -INDUCED ARRHYTHMIA IN ISOLATED GUINEA-PIG ATRIA

Pages

 Start Page | End Page

Keywords

Not Registered.

Abstract

 The effect of paroxetine, Selective serotonin reuptake inhibitors (SSRIs), was studied on ouabain-induced arrhythmia in spontaneously beating isolated guinea-pig atria. paroxetine (4-16×10-5M) produced a dose-dependent decrease in the rate of contractions (22-75%). paroxetine significantly increased the time of onset of arrhythmia induced by Ouabain (1.2µM) when it was administered 10 min before added of ouabain in organ bath. Ouabain (1.2µM) alone produced arrhythmia and either asystole or standstill. paroxetine (8×10-5M) increased the time required to produce arrhythmia to 30 minutes and prolonged beating atria to more than 60 Minutes and prevented the occurrence of asystole. These finding indicated that paroxetine produces direct cardiac action, probably due the inhibition of cardiac Na+ channels. Moreover, our results suggest that paroxetine may reduce the membrane conduction through inhibition of ionic channels which decrease ouabain- induced arrhythmia.

Cites

  • No record.
  • References

  • No record.
  • Related Journal Papers

  • No record.
  • Related Seminar Papers

  • No record.
  • Related Plans

  • No record.
  • Recommended Workshops






    File Not Exists.