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Information Seminar Paper

Title

LONG-TERM EXERCISE EFFECT ON ERYTHROCYTE ANTIOXIDANT ENZYMES AND TOTAL ANTIOXIDANT CAPACITY IN RABBITS FED A HIGH CHOLESTEROL DIET

Writers

ALIPOUR M. | MOHAMMADI M.

Pages

 Start Page | End Page

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Abstract

 Introduction: Despite the knowledge on the antiatherogenic effects of exercise, the mechanism by which exercise reduces atherogenic risk remains unknown. In this study, we investigated the hypothesis that chronic exercise-induced oxidative stress may increase plasma total antioxidant capacity (TAC) and antioxidant defense in the red cells. Methods: For 8 weeks, 60 male rabbit were fed rabbit chow with or without the addition of 2% cholesterol. They were further divided into control and exercise groups. Animals in exercise groups ran on a rodent treadmill at 15m/min for 10 to 60 minutes gradually for 5 days per week for a total of 8 weeks. At the end of experiments, blood samples were collected and plasma TAC levels and activities of glutathione peroxidase (GPX), superoxide dismutase (SOD), and catalase (CAT) were determined in red cells. Aorta and carotid arteries isolated for histopathological examination.Results: Chronic exercise reduced atherogenic diet-induced atherosclerotic lesions in the all arteries, along with enhancement of plasma TAC and erythrocyte catalase activity by exercise in both normal and hypercholesterolemic groups. Total SOD activity rose with exercise only in control group. Surprisingly, GPX activity was reduced significantly in response to exercise in control group and also in high cholesterol diet group.Conclusion: Exercise is a useful tool for the prevention and regression of atherosclerosis and this is along with enhancement of plasma TAC. However, the exercise effects on red cell antioxidants activities is limited in the hypercholesterolemic animals than normal, possibly in part because of alterations in the ability to adapt to exercise–induced oxidative stress in high cholesterol diet.

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