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Information Seminar Paper

Title

PREVENTIVE EFFECT OF N-BUTANOL FRACTION OF NIGELLA SATIVA ON RENAL STONE IN THE RAT

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Abstract

 Introduction: Kidney stones are common. Approximately, %80 of renal stones is composed of calcium oxalate and phosphate. Nigella sativa is a well known medicinal plant with beneficial effect on kidney stones. This study was designed to investigate the effect of N-butanol fraction of Nigella sativa on calcium oxalate renal stone in the rat.Method: Thirty two male Wistar rats were randomly divided into four groups including healthy control, control with ethylen glycol 1% (EG) and prevention groups that received N-butanol fraction and N-butanol phase remnant. Total extracts and N-butanol fraction of Nigella sativa were prepared according to conventional methods. All groups except healthy control rats treated over a 28 day period with EG1% or fractions at equivalent dose of 250mg/kg of total extract. Urine and blood samples were collected from animals at days 0, 14, 28 and 0, 28, respectively. Calcium, magnesium, oxalate and citrate concentrations were measured by using commercial kits. At the end of study, kidneys were removed for histopathology examination. Results: Calcium oxalate crystals significantly increased in EG control group (P<0.001) compared with healthy control rats. Crystals showed a significant reduction in groups received N-butanol fraction and N-butanol phase remnant (P<0.001) in comparison with EG group.Conclusion: These data are consistent with former reports indicating advantageous effect of Nigella sativa on calcium oxalate renal stone disease.

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