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Information Seminar Paper

Title

DIFFERENTIATING NEUROPATHIC FROM INFLAMMATORY PAIN

Writers

MANAHEJI H.

Pages

 Start Page | End Page

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Abstract

 Introduction- Everyone has experienced physical pain on some level. However when we're dealing with pain caused by injury, such as central pain or peripheral neuropathy the normal concept of pain is changed. Pain can be classified in several different ways, inflammatory or neuropathic. As the names suggest, inflammatory pain is associated with tissue or skin inflammed, hot, red, and swollen, while neuropathic pain is associated with injury to peripheral or central nervous system. This article is to describe what happens in nervous system when neuropathic and inflammatory pains occur. Neuropathic pain - Primary sensory neurons are able to signal specific sensory experiences. They communicate with second-order sensory neurons in the spinal cord via specific synaptic neurotransmitters. Following nerve injury, the electrical properties, neurochemistry and central connectivity of these neurons can change. Spontaneous ectopic discharge also arises in the sensory cell bodies in the DRG. Inflammatory pain - when there is tissue injury the threshold for firing of the A∂ and C nociceptive afferent in response to heating of the skin is lowered into the non-noxious range. The mechanism is involved the metabolic synthesis of arachidonic acid and production of prostaglandins, that in turn act directly on the peripheral terminals of A∂ and C fibers, and lower their threshold to noxious stimuli.Differentiating neuropathic from inflammatory pain-The mechanism loading to central sensitization in neuropathic pain may differ from those involved in inflammatory. A characteristic feature of neuropathic pain is allodynia, a condition that can result from central sensitization, but it is uncertain what symptom (S) in a inflammatory pain like arthritis would be analogous to neuropathic allodinya.

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