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Information Seminar Paper

Title

STUDY OF THE ANALGESIC EFFECT OF NAPROXEN SOLID DISPERSIONS IN CROSSPOVIDONE AND ELAEAGNUS ANGUSTIFOLIA FRUIT POWDER USING FORMALIN TEST

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Abstract

 Naproxen is a poor water soluble non-steroidal analgesic and antiinflammatory drug. Increase of dissolution rate by preparing soild dispersions of a drug can improve its own oral absorption as well as effectiveness. The aim of this study is to evaluate analgesic effect of solid disperssions of neproxen (1:1) in crosspovidone and Elaeagnus angustifolia fruit powder by using cogrinding technique and formalin test. Study was carried out in male wistar rats weighing 200±20g (n=8 rats per each group). Formalin test was performed one hour after oral administration of drugs by intraplantar injection of formalin 2.5%. Results obtained from this study show that solid dispersions of naproxen in crosspovidone and Elaeagnus angustifolia produced more (P<0.05) analgesic effect when compared with physical mixtures of naproxen with crosspovidone and Elaeagnus angustifolia and pure naproxen powder. The analgesic effect of physical mixtures of naproxen with crosspovidone and Elaeagnus angustifolia were not significantly different from pure naproxen powder. The analgesic effect of solid dispersions of naproxen-crosspovidone was markedly (P<0.05) more than of solid dispersions of naproxen-Elaeagnus angustifolia. In conclusion we suggest that solid dispersion of naproxen in crosspovidone and Elaeagnus angustifolia fruit powder may increase its analgesic effects.

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