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Information Seminar Paper

Title

EFFECT OF TAMSOLUSIN HCL ON GONADOTHROPIN HORMONE AND TESTOSTERONE IN RAT

Writers

AMIRI J. | RAHIMI S.

Pages

 Start Page | End Page

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Abstract

 Introduction: Tamsulosin HCL is an antagonist of alpha1- adrenoceptor which. Its ability in blocking alpha 1- adrenoceptor is more alpha 2-adrenoceptor. In view of its usage in treating symptoms of with benign prostatic hyperplasia (BPH). The side effects of tamsulosin HCL on the endocrine axise are very important. The aims of thise present research were, to determine the effect of tamsulosin HCL on Gonadothropine hormone and testosterone in adult male rat.METHODS: Forty adult male wistar rats in 5 groups of 8 were selected .The drug was orally administrated in experimental groups for 28 days, experimental groups were given 100, 300, 600 (mg/kg/day) tamsulosin and control group no received drug and schem groupe received water distilled. The blood samples were taken at 28th day and the levels of LH, FSH and testosterone measured by RIA. The results were evaluated by using ANOVA and Duncan tests. The level of significance was considered at p≤0.05.RESULT: The results indicate that receiving different dosage of tamsulosin HCL has no significant effection in levels of LH and FSH among different groups, more over high concentration of drug decreases testosterone levels.Conclusion: According this and other studies the obsord decrease in testosterone level probably due to high level of tamsolusine may has and effect on the activity of steroidogenesis enzymes in testes or influence on the inactivation of adrenergic and serotonergic system which are involve in steroidogengsis. on the results of this study and over previous studies it is concluded that aloha1-adrenoceptor blocked has a potent antifertility effect in male rats.

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