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Title

ACUTE AND SUB-CHRONIC DERMAL TOXICITY OF NANOSILVER IN GUINEA PIG

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Abstract

 Introduction: The present invention provides a colloidal nanosilver solution particles with sizes <100 nm in diameter. The colloidal nanosilver solution of the present invention can be used in sanitary products, solutions for cleansing agents for clothing. It can also be used in health care products, treating patients with all kinds of injuries and/or burns, bacterial and fungal infections.Methods: The Draize test was used to assess primary skin irritation. Before exposure, the test sites were clipped free of hair. At 24 h after each exposure, the sites were scored for erythema (redness), height, and diameter. In the assessment acute and subchronic dermal toxicity, we used different concentration of nanosilver and 1 concentration of AgNO3. The groups in the acute and subchronic dermal toxicity consist of control and test groups. In test group nanosilver in two different. In subchronic dermal toxicity, we used 2 control groups (positive, negative) and 3 test groups. We observed animal’s everyday for 8 to 13 weeks (5 days in a week).Results: In this study, we didn’t investigate variations of macroscopic. But tissue microscopic changes in skin investigated. These changes were in its maximum in the nanosilver concentration of 10000ppm compared to other concentration. The tissue changes of sub-chronic were greater than of acute.Conclusion: Thus, the lengths of exposure and high concentration have direct relationship with the observed changes.

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