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Information Seminar Paper

Title

STUDY EFFECT OF ECHINACEA PURPUREA ON MERCURY- INDUCED NEPHROTOXICITY IN RAT

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Abstract

 Introduction: In acute mercury- induced nephrotoxicity, several pathological changes including cellular necrosis and acute tubular necrosis especially in proximal tubule may be observed. Oxidative stress and lack of antioxidants are some reason for mercury- induced nephrotoxicity. Echinacea purpurea has antioxidative activity. In this study, its effect on mercury- induced nephrotoxicity in rat was evaluated.Methods: In 3 groups of rats, mercury chloride was administrated and 1 group was kept as control.  Echinacea purpurea extract was given along with mercury in one group (prophylactic) and 24 hour after mercury in other group (treatment). After 24, 48 and 72 hours, the rats were euthanized and kidneys removed. Renal tissue was routinely colored and examined by light microscope. Results: Mercury induced acute tubular necrosis, hyperemia and hemorrhage in proximal tubules with +3 severities until 72 hours. In prophylactic group, these lesions were observed with +2 severities until 48 hours and decreased to +1 severity and without hemorrhage after 72 hours. In treatment group, acute tubular necrosis was observed with +1 severity until 48 hours and not seen after 72 hours.Conclusion: This results show, Echinacea can reduce mercury- induced nephrotoxicity by antioxidative property.

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