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Information Seminar Paper

Title

CLINICAL REPORT OF 3 CASES OF POISONING DUE TO ACETAMINOPHEN IN CATS REFERRED TO AHVAZ VETERINARY HOSPITAL

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Abstract

  Acetaminophen is a widely available analgesic/antipyretic contained in many over – the – counter preparations intended for human use. Exposure to cats occurs though administration of one of these preparations by an uninformed but well-meaning owner intending to treat fever or pain perceived in the pet, or by accidental ingestion of a toxic dose. Cats are extremely sensitive to the toxic effects of acetaminophen (due to defect in hepatic glucuronyle transferees) and can develop clinical signs of toxicity with dosages in the range of 50 to 100 mg/kg, so administration of this drug is not recommended in cats. The most common clinical signs reported include hemolytic anemia due to methemoglobolinemia, respiratory distress, cyanosis, edema of the face and paws, depression, icterus, hypothermia and vomiting. In recent report, 3 cats with age 5-9 months and DSH (Domestic short hair) breed were referred with signs cyanosis, depression, hypothermia, anorexia and respiratory distress. In history, it was detected that clients administrated this drug for 3-5 days and with dosage 50-75 mg/kg. As situation of these animals were emergency, treatment was done with N-acetylcysteine (140 mg/kg, IV q 6 h, then with dosage 70 mg/kg for 5 times). Also fluid therapy was administrated in affected animals. Blood transfusion wasn’t injected to them, because PCV was normal (over 30). Animal’s status was satisfactory after few days. Due to death risk resulting from acetaminophen usage in animals, required information giving is obligatory for clients about lack of drug usage.

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