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Information Seminar Paper

Title

ACUTE AND SUBCHRONIC TOXICITY OF ECHINOPHORA PLATYLOBA TOTAL EXTRACT IN WISTAR RATS

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Abstract

 The Echinophora platyloba is represented in the flora of Iran. There are reports about its antimicrobial and antifungal activity and can used against some dermatophytes. However there is no report about possible toxic effects. In this study we evaluated acute and subchronic toxicity of P.E in wistar rats. For acute toxicity, six groups of 4 rats of each sex received orally four different single dose of total extract. Rats were observed for mortality twice daily during of study and body weight were taken weekly. After 14 days the animals scarified and gross necroscopy were performed. In the subchronic toxicity, 32 rats were equally distributed into four groups of each sex and three concentration of extract (50, 200, 500mg/kg) were administrated via oral intubations. Rats were observed for mortality and behavioral changes. At the end of study, the animals were scarified and the hematological and biochemical parameters, and weight of liver, heart, kidney and lung was recorded, and histopathoyl of tissues was assayed. In the acute study all of rats alive during 14 days observation therefore the LD50 of E.Platyboa is higher than 5mg/kg. The result of subchronic study showed any significant difference in hematological and biochemical parameters in both sexes. The result of histopathology examination showed Intraalveolar hemorrhage in the male rats (500mg/kg). In the females (200 mg/kg) congestion of alveolar capillaries and liver Bridging necrosis significantly increase compare to respective control. In the other organs was not show any significant difference. It is concluded that E.platyloba haven’t any sever toxicity in the wistar rats during our study.

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