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Information Seminar Paper

Title

EFFECT OF DIFFERENT DOSAGES OF PHENOBARBITAL ON LEARNING AND BRAIN WEIGHT IN RAT

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Abstract

 Introduction: All antiepileptic drugs have the potential for adverse effects on cognition and behavior. The present study examined the effect of chronic phenobarbital administration on learning and whole brain weight in rats.Methods: One-month male Wistar rats received phenobarbital (PB) at 50, 75, 100mg/kg intraperitoneally (IP) and an equivalent volume of saline for controls for 45 days. The learning and memory were assessed using passive avoidance tests. The animals were anesthetized and trans-cardially perfused with a 10% formaldehyde solution. The brain was removed and weighed.Results: There was no significant change in learning at dose of 50 mg/kg PB. However, at 75 and 100mg/kg, PB caused impairment in learning. Even though there were no differences among controls and 50mg/kg PB treated animals, the group receiving 75 and 100mg/kg PB had significantly smaller whole brain weights than the other groups.Conclusion: The results indicate that chronic PB administration may not be linked to impaired learning function at doses used in anticonvulsant therapy. The data also suggest PB exposure may constitute a threat to normal brain growth. Our findings present a potential cause for the learning deficits induced by PB.

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