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Information Seminar Paper

Title

TOXICITY EFFECT OF ROSA DAMASCENA

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Abstract

 Introduction: the use of plant drugs is increasing every day. It is important to investigate toxicity of this plant. In this study, we investigated toxicity effect of the ethanol crude extract of Rosa damascena and further fractionated extracts with water, ethyl acetate and n-butanol in mice.Methods: the dried plant was extracted by digestion method, then the extract was dissolved in water and the solution was extracted with ethyl acetate and n-butanol. The ethyl acetate and n-butanol were discarded to obtain aqueous fraction. For the assessment of toxicity, this investigation was done in two stages: acute and sub-acute toxicity. In the acute stage, after intraperitoneal injection of several doses of extract and fraction, behavior and mortality rate were observed. After assessment of the dosage with no mortality, mice were fed with theses doses orally for 21 days. Then, mice were killed and the effect of extract and fractions on the liver weight and its enzymes were investigated.Results: ethanol extract and fractions of Rosa damascena at the dosages 1, 2 and 4gr/kg for n-butanol and ethanol extract and dosages 1.2, 0.6, 0.3 and 0.2gr/kg for ethyl acetate and dosage 1.2 gr/kg for water fraction were killed the mice. The dose 0.5gr/kg of n-butanul and ethanol extract, the dose 0.8 gr/kg of water fraction and the dose 0.1gr/kg of ethyl acetate were not killed the mice. In the investigations for sub acute effects, we didn't observe any changes in the liver weight, creatinin level and liver enzymes compared to the control group.

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