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Title

THE EFFECT OF ENDURANCE EXERCISE TRAINING AND ATORVASTATIN ON VEGF IN RAT FOLLOWING EXPERIMENTAL MYOCARDIAL INFARCTION

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 Start Page 21 | End Page 31

Abstract

 Introduction: Statins and exercise training may have synergic beneficial effects onangiogenesis process following MYOCARDIAL INFARCTION. Therefore, the present study aimed to investigate the effect of ENDURANCE EXERCISE TRAINING (EET), ATORVASTATIN and their combination on expression of vascular endothelial growth factor (VEGF) in the cardiac muscle of male RAT following experimental MYOCARDIAL INFARCTION.Materials & methods: 45 RATs (8-10 week sold, 230±10 g body weight) were randomly divided to five groups: Sham, control, EET, ATORVASTATIN, and EET+atorvastatin. MYOCARDIAL INFARCTION was induced by subcutaneous injection of isoprenaline (150 mg/kg) in two consecutive days. Drug and training interventions were initiated 2 days after infarction and continued for 4 weeks.In order to assess the expression of VEGF, immunohis to chemical staining was used.Data were analyzed by using one-way analyses of variance (ANOVA) and scheffe test at P<0.05 level.Findings: VEGF expression in theatorvastatin group was significantly lessthan the control group (P=0.006). Also, VEGF expression in the Combined (EET+atorvastatin) and EET groups was not significant (P=0.534 and P=0.055respectively), but its expression was significantly higher in the combined group (EET+atorvastatin) compared to the EETgroup (P=0.002) and ATORVASTATIN group(P=0.001).Discussion & conclusion: It seems that combination of EET and ATORVASTATINcompared to EET and or ATORVASTATIN alonehas a favorable effect on VEGF expression and as a result, on angiogenesis process following MYOCARDIAL INFARCTION.

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