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Title

ALUMINUM LEVELS IN THE SERA OF PATIENTS WITH ALZHEIMER'S DISEASE AND ITS RELATIONSHIP WITH DISEASE STAGE 3 COMPARED WITH CONTROL GROUP

Writers

TABATABAEE M.

Pages

 Start Page 126 | End Page 132

Keywords

ALZHEIMER'S DISEASE (AD)Q1

Abstract

 Introduction: Alzheimer's disease (AD) is one of the neurodegenerative diseases which is associated with cognitive, behavior and motoral impairments. The main symptom of this disease is dementia, which may cause difficulties in carrying out daily practices. According to multifactorial nature of the disease and its several causin gfactors, studies have raised the hypothesisthat serum levels of some metals may beinvolved in causing of AD. One of these metals is ALUMINUM. The aim of this study was to evaluate ALUMINUM levels in Alzheimer patient's serum with severity of disease on one hand and comparing it inpatients and healthy individuals on theother hand.Materials & methods: In this study a groupof patients with a definite diagnosis of Alzheimer's disease were assessed with GLOBAL DETERIORATION SCALE (GDS) for severity of illness. The amount of ALUMINUM in serum was measured byatomic absorption spectro photometry ineach patient and control groups. There lationship between the ALUMINUM and theseverity of disease was examined.Findings: 50 patients (26 male/ 24 female) and 50 healthy subjects (29 male/ 21 female) were enrolled in the study. Serumic ALUMINUM levels in patients and controls were 37.17±17μg/L and 23.38±30 μg/Lrespectively (p=0.006). Also the serumi caluminum was sign ificantly associated with severity of disease (r=0.913 and p<0.001).Discussion & Conclusions: The study indicated that sign ificant differences of these rumic ALUMINUM levels between Alzheimer's disease and normal subjectsand ALUMINUM can be raised as aenvironmental factor in causing & severityof AD.

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