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Title

SYNTHESIS OF 4- (2-METHYLTHIAZOL-4-YL) - HEXAHYDROQUINOLINE AND 1, 4-DIHYDROPYRIMIDIN DERIVATIVES

Pages

 Start Page 21 | End Page 25

Abstract

 A series of new hexahydroquinoline and 1, 4-dihydropyrimidine derivatives were synthesized. Condensation of 2-methyl- thiazole-4-carboxaldehyde (1) with 1, 3-cyclohexanedione and alkyl 3- aminocrotonate afforded 4- (2-methyl-thiazol- 4-yl) -hexahydroquinoline while condensation of aldehyde (1) with benzoyl acetone and thiourea gave 1, 4-dihydropyrimidine derivatives. The stereochemistry of 1, 4-dihydropyrimidine derivatives were studied using 1HNMR.

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