Journal Paper

Paper Information

Journal: ADVANCES IN COGNITIVE SCIENCE | Year:1386 | Volume:9 | Issue:3 (35) | Start Page:1 | End Page:8

video

sound

Persian Version

View:

176

Download:

98

Cites:

Information Journal Paper

Title

THE EFFECT OF REPEATED HISTAMINE ADMINISTRATION ON THE RETRIEVAL OF LITHIUM STATE DEPENDENT LEARNING IN MICE

Pages

 Start Page 1 | End Page 8

Abstract

 Objective: In the present study the effect of histamine SENSITIZATION on the retrieval of passive avoidance memory was investigated.Method: One-trail step-down passive avoidance task was used to assess memory in adult male NMRI mice.Results: Post training administration of LITHIUM (10 mg/kg) impaired the memory on the training day, and pre-test administration of LITHIUM prevented the impairment of memory (p<0.001). SENSITIZATION was induced using daily injections of 20 mg/mouse histamine in three consecutive days followed by five drug-free days. The LITHIUM-induced impaired memory was restored better in mice sensitized with histamine than in non-sensitized mice (p<0.01). On the other hand, frequent injection (three days injection followed by five drug free days) of the H1 receptor antagonist PYRILAMINE (40 mg/mouse), and the H2 receptor antagonist RANITIDINE (6.25 and 12.5 mg/mouse), prevented the restoration of impaired memory.Conclusion: Histamine SENSITIZATION affects memory impairment induced by LITHIUM; therefore, it is postulated that signaling cascade from HISTAMINE RECEPTORS may mediate the effects of LITHIUM on memory in passive avoidance task.

Cites

  • No record.
  • References

    Related Journal Papers

    Related Seminar Papers

  • No record.
  • Related Plans

  • No record.





  • Advertising

    مرکز اطلاعات علمی SID
    مرکز اطلاعات علمی SID
    مرکز اطلاعات علمی SID
    مرکز اطلاعات علمی SID
    مرکز اطلاعات علمی SID
    مرکز اطلاعات علمی SID
    مرکز اطلاعات علمی SID
    مرکز اطلاعات علمی SID