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Information Journal Paper

Title

EFFECT OF HYDROGEN SULPHIDE ON MOTOR ACTIVITY IN MICE JEJUNUM

Writers

RAHMATI REZA | GRUNDY D.

Pages

 Start Page 16 | End Page 20

Abstract

 Background and Objective: Biological activity of hydrogen supplied in smooth muscle of vessel and non-vessel tissue are contradictory. The aim of this study was to examine the effect of hydrogen sulphide on smooth activity of muscle MICE jejunum.Materials and Methods: Experiments were performed on MICE jejunum and MOTOR ACTIVITY was recorded from in vitro segments of jejunum ~ 4 cm in length. jejunal segments were mounted horizontally in separate perfusion chamber. Furthermore, using vanilloid receptor 1 deficient MICE (VR 1-/-) we tested hypothesis that extrinsic sensory nerves mediated alterations, in MOTOR ACTIVITY responses in the presence different concentration of of hydrogen sulphide (100-3000 mM).Results: Serosal application of NaHS (as hydrogen sulphide donor) produced a dose-dependent inhibition of MOTOR ACTIVITY that are not significantly different between VR 1-/- and VR 1 +/+ MICE. In the presence of TTX (1mM) NaHS (300mM) caused a reduction in basal tone (19.5%, p<0.05, n=5) and inhibited the contraction evoked by 30mM bethanechol by 55% (n=5, p<0.05). Conclusion: This study showed that hydrogen sulphide is an important MOTOR ACTIVITY inhibitor in MICE jejunum.

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